Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285878 | 0.97 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL286025 | 0.91 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL285561 | 0.90 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL285612 | 0.90 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL285611 | 0.90 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL285864 | 0.89 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL285855 | 0.88 | GABRA5 (0.68) | GABRA5GABRA1 | |
| SCHEMBL286077 | 0.86 | GABRA5 (0.67) | GABRA5GABRA1 | |
| SCHEMBL535819 | 0.86 | GABRA5 (0.55) | GABRA5GABRA1 | |
| SCHEMBL107842 | 0.85 | GABRA5 (0.52) | GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427457-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127978-A1 | ISOXAZOLE-PYRIDINE DERIVATIVES AS GABA MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |