Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586946 | 0.91 | TDP1 (0.45) | MAPTTDP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL586674 | 0.87 | NOTUM (0.44) | MAPTTDP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL5258300 | 0.86 | TDP1 (0.45) | MAPTTDP1MAPK1KDM4EALDH1A1 | |
| SCHEMBL27128033 | 0.86 | NR1H2 (0.47) | MAPTSTSKDM4EALDH1A1PTPN2 | |
| SCHEMBL26984184 | 0.86 | NR1H2 (0.47) | MAPTSTSKDM4EALDH1A1PTPN2 | |
| SCHEMBL31136848 | 0.84 | MAPT (0.43) | MAPTSTSTDP1MAPK1KDM4E | |
| SCHEMBL586744 | 0.83 | SLC6A2 (0.46) | MAPTTDP1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL582132 | 0.82 | NOTUM (0.47) | TDP1MAPK1KDM4EALDH1A1POLB | |
| SCHEMBL18406189 | 0.81 | MAPT (0.49) | MAPTALDH1A1P2RY14GPR119RORC | |
| SCHEMBL586920 | 0.78 | MAPT (0.42) | MAPTTDP1MAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| US-7638629-B2 | Piperidines and related compounds for treatment of alzheimer's disease | Merck Sharp & Dohme Ltd, (GB) | 2009-12-29 | — | — | US | disclosed |