Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL586946 | 0.96 | TDP1 (0.45) | NOTUMTDP1MAPK1ALDH1A1GAA | |
| SCHEMBL582132 | 0.96 | NOTUM (0.47) | NOTUMTDP1MAPK1ALDH1A1GAA | |
| SCHEMBL5258300 | 0.89 | TDP1 (0.45) | NOTUMTDP1MAPK1ALDH1A1GAA | |
| SCHEMBL587349 | 0.88 | MMP1 (0.41) | NOTUM | |
| SCHEMBL586941 | 0.88 | NOTUM (0.45) | NOTUMTDP1ALDH1A1GAAKDM4E | |
| SCHEMBL2859600 | 0.87 | MAPT (0.43) | TDP1MAPK1ALDH1A1GAAKDM4E | |
| SCHEMBL587057 | 0.85 | TACR1 (0.40) | NOTUMTDP1MAPT | |
| SCHEMBL587433 | 0.85 | SMN1; SMN2 (0.44) | NOTUMMAPT | |
| SCHEMBL586744 | 0.85 | SLC6A2 (0.46) | TDP1ALDH1A1KDM4EMAPTCYP3A4 | |
| SCHEMBL581263 | 0.85 | SLC6A2 (0.41) | TDP1ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |