Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 6/20 | 0.54 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.54 |
| ▸ | NPY4R | P50391 | 4/20 | 0.54 |
| ▸ | NPY1R | P25929 | 3/20 | 0.54 |
| ▸ | NPY2R | P49146 | 3/20 | 0.54 |
| ▸ | ENPEP | Q07075 | 3/20 | 0.53 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.52 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.48 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.48 |
| ▸ | CTSD | P07339 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL285960 | 1.00 | BACE1 (0.54) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL285712 | 0.95 | NAALAD2 (0.58) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL29854734 | 0.95 | NAALAD2 (0.58) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL31710009 | 0.95 | NAALAD2 (0.58) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL29693799 | 0.95 | NAALAD2 (0.58) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL4420809 | 0.93 | ENPEP (0.56) | BACE1BACE2NPY4RNPY1RNPY2R | |
| SCHEMBL8775818 | 0.93 | NPY4R (0.58) | NPY4RNPY1RNPY2RNAALAD2ERAP2 | |
| SCHEMBL31706956 | 0.93 | NAALAD2 (0.57) | NPY4RNPY1RNPY2RENPEPNAALAD2 | |
| SCHEMBL5032917 | 0.92 | ENPEP (0.56) | NPY4RNPY1RNPY2RENPEPERAP2 | |
| SCHEMBL29865452 | 0.92 | ENPEP (0.58) | NPY4RNPY1RNPY2RENPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102574909-A | Methods of modifying serine protease inhibitors | NATURAL ENVIRONMENT RES COUNCIL | 2012-07-11 | — | — | CN | disclosed |
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |
| EP-2427487-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | Natural Environment Research Council (GB) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128285-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2010-11-11 | — | — | WO | disclosed |