Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 3/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 6/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.39 |
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956407 | 0.91 | KDR (0.48) | KDRAURKBNUAK1FLT4AURKA | |
| SCHEMBL27059432 | 0.88 | KDR (0.49) | KDRAURKBFLT4AURKAJAK3 | |
| SCHEMBL28919841 | 0.86 | JAK2 (0.40) | NUAK1JAK3JAK2JAK1TYK2 | |
| SCHEMBL30956426 | 0.82 | FLT4 (0.46) | KDRAURKBNUAK1FLT4JAK3 | |
| SCHEMBL28606148 | 0.81 | IGF1R (0.44) | FLT4JAK3JAK2JAK1TYK2 | |
| SCHEMBL24852480 | 0.81 | JAK3 (0.48) | JAK3JAK2JAK1TYK2IGF1R | |
| SCHEMBL30956612 | 0.80 | JAK3 (0.49) | NUAK1FLT4JAK3JAK2JAK1 | |
| SCHEMBL30956449 | 0.80 | KDR (0.45) | KDRAURKBFLT4JAK3JAK2 | |
| Hydrochloric Acid SCHEMBL30956501 | 0.80 | NUAK1 (0.55) | KDRAURKBNUAK1FLT4JAK3 | |
| SCHEMBL22098030 | 0.79 | JAK2 (0.44) | KDRFLT4JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |