Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 15/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | CDK7 | P50613 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30956391 | 0.91 | IGF1R (0.47) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24852445 | 0.89 | IGF1R (0.47) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24853191 | 0.84 | IGF1R (0.46) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL28919841 | 0.84 | JAK2 (0.40) | IGF1RJAK2JAK3MAP4K1TYK2 | |
| SCHEMBL30956427 | 0.83 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL30956561 | 0.82 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL28598709 | 0.81 | KDR (0.46) | IGF1RJAK2JAK3MAP4K1TYK2 | |
| SCHEMBL24852480 | 0.80 | JAK3 (0.48) | IGF1RJAK2JAK3MAP4K1TYK2 | |
| SCHEMBL30956408 | 0.80 | IGF1R (0.49) | IGF1RCDK1CDK2CDK8CDK7 | |
| SCHEMBL24853511 | 0.79 | IGF1R (0.48) | IGF1RCDK1CDK2CDK8CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290403-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl and compositions and methods thereof | 凌科药业(杭州)有限公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-113227074-A | Benzamide derivatives of pyrazolyl-amino-pyrimidinyl derivatives, compositions and methods | 凌科药业(杭州)有限公司 | 2021-08-06 | — | — | CN | disclosed |