Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.43 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.38 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPY4R | P50391 | 3/20 | 0.35 |
| ▸ | NPY1R | P25929 | 2/20 | 0.35 |
| ▸ | NPY2R | P49146 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL29129604 | 1.00 | CTSC (0.43) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL515138 | 1.00 | CTSC (0.43) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL28444628 | 0.98 | CTSC (0.42) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL27385572 | 0.98 | CTSC (0.42) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL11905110 | 0.97 | ALPI (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL27686839 | 0.96 | CTSC (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL5071059 | 0.96 | CTSC (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL3656565 | 0.96 | CTSC (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL10428541 | 0.95 | CTSC (0.40) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL4284805 | 0.95 | CTSC (0.40) | CTSCALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180119198-A1 | Methods, Compositions and Kits for High Throughput Kinase Activity Screening Using Mass Spectrometry and Stable Isotopes | HARVARD COLLEGE (US) | 2018-05-03 | — | — | US | claimed |
| EP-2347263-B1 | METHODS, COMPOSITIONS AND KITS FOR HIGH THROUGHPUT KINASE ACTIVITY SCREENING USING MASS SPECTROMETRY AND STABLE ISOTOPES | HARVARD COLLEGE (US) | 2017-05-17 | — | — | EP | claimed |
| US-9091700-B2 | Modified peptide substrate | MCMASTER UNIVERSITY (CA) | 2015-07-28 | — | — | US | claimed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | claimed |
| US-20110269161-A1 | Methods, Compositions and Kits for High Throughput Kinase Activity Screening Using Mass Spectrometry and Stable Isotopes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-11-03 | — | — | US | claimed |
| CN-108707184-B | Mass spectrum probe for thrombin activity detection and preparation method and application thereof | 浙江大学 | 2021-01-29 | — | — | CN | disclosed |
| US-10407712-B2 | Methods, compositions and kits for high throughput kinase activity screening using mass spectrometry and stable isotopes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-09-10 | — | — | US | disclosed |
| US-10131932-B2 | Method for assaying a protease | MCMASTER UNIVERSITY | 2018-11-20 | — | — | US | disclosed |
| EP-3047033-B1 | METHOD FOR ASSAYING A PROTEASE | UNIV MCMASTER (CA) | 2018-08-22 | — | — | EP | disclosed |
| US-20180119198-A1 | Methods, Compositions and Kits for High Throughput Kinase Activity Screening Using Mass Spectrometry and Stable Isotopes | HARVARD COLLEGE (US) | 2018-05-03 | — | — | US | disclosed |
| EP-2347263-B1 | METHODS, COMPOSITIONS AND KITS FOR HIGH THROUGHPUT KINASE ACTIVITY SCREENING USING MASS SPECTROMETRY AND STABLE ISOTOPES | HARVARD COLLEGE (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20160326569-A1 | METHOD FOR ASSAYING A PROTEASE | MCMASTER UNIVERSITY (CA) | 2016-11-10 | — | — | US | disclosed |
| US-20120208225-A1 | MODIFIED PEPTIDE SUBSTRATE | THE UNIVERSITY OF MELBOURNE (AU) | 2012-08-16 | — | — | US | disclosed |
| US-20120135931-A1 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2012-05-31 | — | — | US | disclosed |
| EP-2427487-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | Natural Environment Research Council (GB) | 2012-03-14 | — | — | EP | disclosed |
| US-20110269161-A1 | Methods, Compositions and Kits for High Throughput Kinase Activity Screening Using Mass Spectrometry and Stable Isotopes | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-11-03 | — | — | US | disclosed |
| WO-2010128285-A2 | METHOD OF MODIFYING SERINE PROTEASE INHIBITORS | NATURAL ENVIRONMENT RESEARCH COUNCIL (GB) | 2010-11-11 | — | — | WO | disclosed |
| EP-0948308-A1 | METHODS FOR TREATING SKIN PIGMENTATION | JOHNSON & JOHNSON CONSUMER PRODUCTS, INC. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1999004752-A9 | METHODS FOR TREATING SKIN PIGMENTATION | JOHNSON & JOHNSON CONSUMER (US) | 1999-04-08 | — | — | WO | disclosed |
| WO-1999004752-A2 | METHODS FOR TREATING SKIN PIGMENTATION | JOHNSON & JOHNSON CONSUMER COMPANIES, INC. (US) | 1999-02-04 | — | — | WO | disclosed |