Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 2/20 | 0.41 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.36 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.36 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPY4R | P50391 | 3/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | NPY2R | P49146 | 2/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL285989 | 0.96 | CTSC (0.43) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL29129604 | 0.96 | CTSC (0.43) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL515138 | 0.96 | CTSC (0.43) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL28522483 | 0.95 | CTSC (0.39) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL28444628 | 0.95 | CTSC (0.42) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL27385572 | 0.95 | CTSC (0.42) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL11147102 | 0.94 | CTSC (0.37) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL11905110 | 0.94 | ALPI (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL27686839 | 0.93 | CTSC (0.41) | CTSCALPIPKMPTGS1XIAP | |
| Arginine SCHEMBL5071059 | 0.93 | CTSC (0.41) | CTSCALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2215260-A1 | COMPOSITIONS AND METHODS FOR MODULATING CELLULAR MEMBRANE-MEDIATED INTRACELLULAR SIGNAL TRANSDUCTION | REVALESIO CORPORATION (US) | 2010-08-11 | — | — | EP | disclosed |
| WO-2009055614-A1 | COMPOSITIONS AND METHODS FOR MODULATING CELLULAR MEMBRANE-MEDIATED INTRACELLULAR SIGNAL TRANSDUCTION | REVALESIO CORPORATION (US) | 2009-04-30 | — | — | WO | disclosed |