Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | PRKCI | P41743 | 2/20 | 0.53 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | CHUK | O15111 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173343 | 1.00 | AXL (0.53) | AXLPRKCIRPS6KA3MAPK1MAPK14 | |
| SCHEMBL30173316 | 0.84 | AXL (0.61) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL28609163 | 0.84 | AXL (0.61) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL30173305 | 0.84 | JAK2 (0.58) | AXLPRKCIRPS6KA3MAPK1CLK2 | |
| SCHEMBL3725709 | 0.84 | JAK2 (0.58) | AXLPRKCIRPS6KA3MAPK1CLK2 | |
| SCHEMBL28596894 | 0.84 | RPS6KA3 (0.49) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL28596900 | 0.84 | AXL (0.49) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL30173331 | 0.84 | AXL (0.49) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL30173298 | 0.84 | RPS6KA3 (0.49) | AXLPRKCIRPS6KA3CLK2DYRK1A | |
| SCHEMBL30173308 | 0.81 | AXL (0.53) | AXLPRKCIMAPK1DYRK1ACLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200983-B | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2023-01-03 | — | — | CN | disclosed |
| CN-113200983-A | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-03 | — | — | CN | disclosed |