Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.63 |
| ▸ | JAK2 | O60674 | 8/20 | 0.63 |
| ▸ | JAK3 | P52333 | 3/20 | 0.61 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | AXL | P30530 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.45 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30173329 | 1.00 | JAK1 (0.63) | JAK1JAK2JAK3HPGDSAXL | |
| SCHEMBL30173276 | 0.91 | JAK2 (0.72) | JAK1JAK2JAK3HPGDSAXL | |
| SCHEMBL28919002 | 0.91 | JAK2 (0.72) | JAK1JAK2JAK3HPGDSAXL | |
| SCHEMBL28603790 | 0.87 | JAK1 (0.72) | JAK1JAK2JAK3HPGDS | |
| SCHEMBL30173268 | 0.87 | JAK1 (0.72) | JAK1JAK2JAK3HPGDS | |
| SCHEMBL28596869 | 0.83 | JAK1 (0.69) | JAK1JAK2JAK3 | |
| SCHEMBL30173344 | 0.83 | JAK1 (0.69) | JAK1JAK2JAK3 | |
| SCHEMBL28608389 | 0.83 | JAK1 (0.69) | JAK1JAK2HPGDS | |
| SCHEMBL30173275 | 0.83 | JAK1 (0.69) | JAK1JAK2HPGDS | |
| SCHEMBL30173293 | 0.81 | JAK1 (0.67) | JAK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113200983-B | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2023-01-03 | — | — | CN | disclosed |
| CN-113200983-A | Compound with pyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-03 | — | — | CN | disclosed |