SCHEMBL28601543

SCHEMBL28601543

CNc1nc(N)nc2c1ncn2[C@@H]1O[C@H](C[O])[C@@H](O)[C@@]1(C)F

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ADORA3 P0DMS8 10/20 0.56
ADORA1 P30542 10/20 0.56
ADORA2B P29275 8/20 0.52
PGK1 P00558 1/20 0.43
PGK2 P07205 1/20 0.43
NT5E P21589 1/20 0.42
ADORA2A P29274 5/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19777948 0.92 ADORA3 (0.56) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL21015437 0.92 ADORA3 (0.56) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28932189 0.91 ADORA3 (0.57) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL29363191 0.91 ADORA3 (0.65) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL26326162 0.91 ADORA3 (0.57) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL25204813 0.91 ADORA3 (0.65) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL18041228 0.91 ADORA3 (0.65) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL18061792 0.91 ADORA3 (0.65) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL28678580 0.89 ADORA3 (0.55) ADORA3ADORA1ADORA2BPGK1PGK2
SCHEMBL26326125 0.88 ADORA3 (0.54) ADORA3ADORA1ADORA2BPGK1PGK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113164505-A High activity pharmaceutical combination for treating hepatitis C virus 阿堤亚制药公司 2021-07-23 CN disclosed