Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.59 |
| ▸ | BTK | Q06187 | 3/20 | 0.53 |
| ▸ | JAK3 | P52333 | 2/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.51 |
| ▸ | SYK | P43405 | 2/20 | 0.50 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 3/20 | 0.46 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.44 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.44 |
| ▸ | ITGAL | P20701 | 1/20 | 0.44 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28601566 | 1.00 | MAP4K4 (0.59) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL27938543 | 0.85 | MAP4K4 (0.62) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL23104518 | 0.81 | MAP4K4 (0.66) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL12804703 | 0.81 | MAP4K4 (0.60) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL16765873 | 0.81 | KIF18A (0.62) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL16765875 | 0.81 | KIF18A (0.62) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL15609396 | 0.80 | MAP4K4 (0.58) | MAP4K4BTKJAK3PDE10ASYK | |
| SCHEMBL28601565 | 0.80 | ACACB (0.42) | MAP4K4 | |
| SCHEMBL1351335 | 0.79 | ACACB (0.52) | MAP4K4PDE10ASYKITGB2ICAM1 | |
| SCHEMBL29689898 | 0.79 | ACACB (0.52) | MAP4K4PDE10ASYKITGB2ICAM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164461-A | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2021-07-23 | — | — | CN | disclosed |