Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.38 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.34 |
| ▸ | HBB | P68871 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855457 | 0.89 | MEN1 (0.50) | MEN1KMT2AKDM4EPOLBKEAP1 | |
| SCHEMBL2855458 | 0.88 | KMT2A (0.44) | MEN1KMT2AKDM4EPOLBKEAP1 | |
| SCHEMBL2857489 | 0.82 | HSPB1 (0.54) | MEN1KMT2AKDM4EPOLBLMNA | |
| SCHEMBL2857491 | 0.82 | HSPB1 (0.54) | MEN1KMT2AKDM4EPOLBLMNA | |
| SCHEMBL2852227 | 0.80 | KDM4E (0.52) | MEN1KMT2AKDM4EPOLBKEAP1 | |
| SCHEMBL2864471 | 0.78 | BRAF (0.37) | LMNAMETALDH1A1NPC1RAB9A | |
| SCHEMBL4314966 | 0.77 | MEN1 (0.53) | MEN1KMT2AKDM4EKEAP1ALOX5AP | |
| SCHEMBL2860604 | 0.77 | MEN1 (0.53) | MEN1KMT2AKDM4EPOLBKEAP1 | |
| SCHEMBL2857370 | 0.76 | BRAF (0.48) | — | |
| SCHEMBL3510993 | 0.75 | KMT2A (0.43) | MEN1KMT2AKDM4EPOLBKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |