Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 6/20 | 0.52 |
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | CLK2 | P49760 | 2/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PRKCG | P05129 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | FES | P07332 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.52 |
| ▸ | FER | P16591 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | CDK2 | P24941 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28558865 | 0.77 | DYRK1A (0.34) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL1564760 | 0.75 | ITK (0.54) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL28603327 | 0.75 | DYRK1A (0.63) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL28674867 | 0.73 | PDPK1 (0.52) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL30301157 | 0.73 | PDPK1 (0.52) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL1565867 | 0.72 | DYRK1A (0.54) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL22820704 | 0.72 | KMT2A (0.43) | DYRK1AMAP4K4MINK1TNIK | |
| SCHEMBL28605172 | 0.71 | DYRK1A (0.55) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL1516812 | 0.70 | DYRK1A (0.65) | DYRK1AJAK2CLK2CLK4PLK4 | |
| SCHEMBL18392230 | 0.70 | DYRK1A (0.54) | DYRK1AJAK2CLK2CLK4PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214247-A | Azaindole derivative marrow cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-08-06 | — | — | CN | disclosed |