Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 5/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.34 |
| ▸ | FLT1 | P17948 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.34 |
| ▸ | CLK2 | P49760 | 3/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | JAK3 | P52333 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28607892 | 0.77 | DYRK1A (0.52) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL28556801 | 0.76 | IDO1 (0.44) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL28549353 | 0.72 | KIT (0.45) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL16537147 | 0.71 | DYRK1B (0.44) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL28553148 | 0.69 | DYRK1B (0.56) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL5061384 | 0.69 | DYRK1A (0.57) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL28559332 | 0.68 | DYRK1A (0.44) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL22820704 | 0.68 | KMT2A (0.43) | DYRK1AMAP4K4MINK1MET | |
| SCHEMBL29930538 | 0.68 | DYRK1B (0.60) | DYRK1ADYRK1BAURKAJAK2MAP4K4 | |
| SCHEMBL29930770 | 0.67 | DYRK1B (0.58) | DYRK1ADYRK1BAURKAJAK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112724134-B | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2022-04-01 | — | — | CN | disclosed |
| CN-112724134-A | Azaindazole bipyridine derivative myeloid cell proliferation inhibitor, preparation method and application thereof in pharmacy | 复旦大学 | 2021-04-30 | — | — | CN | disclosed |