SCHEMBL28609306

SCHEMBL28609306

CC(Nc1cc(Br)cnc1N)[C@@H](C)C(=O)O

nearest known ligand 0.40

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 6/20 0.40
HTT P42858 2/20 0.40
LDHA P00338 2/20 0.39
LDHB P07195 2/20 0.39
MEN1 O00255 5/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
POLB P06746 2/20 0.33
KDM4E B2RXH2 2/20 0.32
HSD17B10 Q99714 2/20 0.32
CCNA2 P20248 1/20 0.32
CDK2 P24941 1/20 0.32
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
BLM P54132 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HCAR3 P49019 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22011055 0.87 LDHA (0.39) KMT2AHTTLDHALDHBMEN1
SCHEMBL19836479 0.81 KMT2A (0.50) KMT2AHTTLDHALDHBMEN1
SCHEMBL23532176 0.77 AAK1 (0.42)
SCHEMBL22010535 0.76 LDHA (0.37) KMT2AHTTLDHALDHBMEN1
SCHEMBL22011048 0.76 HSD17B10 (0.42) KMT2AHTTMEN1NPC1ALDH1A1
Hydrochloric Acid SCHEMBL21963994 0.75 LDHA (0.37) KMT2AHTTLDHALDHBMEN1
SCHEMBL25299222 0.74 KMT2A (0.47) KMT2AHTTLDHALDHBMEN1
SCHEMBL21963969 0.73 KMT2A (0.37) KMT2AHTTLDHALDHBMEN1
SCHEMBL22010774 0.73 KMT2A (0.37) KMT2AHTTLDHALDHBMEN1
SCHEMBL30161448 0.73 KMT2A (0.37) KMT2AHTTLDHALDHBMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113272302-A Antibiotic compounds, process for their manufacture, pharmaceutical compositions containing them and their use 德彪药业国际股份公司 2021-08-17 CN disclosed