Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 13/20 | 0.40 |
| ▸ | TXK | P42681 | 5/20 | 0.40 |
| ▸ | ITK | Q08881 | 5/20 | 0.40 |
| ▸ | BMX | P51813 | 4/20 | 0.40 |
| ▸ | TEC | P42680 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CD69 | Q07108 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | S100A4 | P26447 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28610069 | 1.00 | BTK (0.40) | BTKTXKITKBMXTEC | |
| SCHEMBL28601489 | 0.86 | SMN1; SMN2 (0.46) | KMT2AMEN1S100A4 | |
| SCHEMBL28601493 | 0.86 | SMN1; SMN2 (0.46) | KMT2AMEN1S100A4 | |
| SCHEMBL31124490 | 0.83 | BTK (0.54) | BTKKMT2AMEN1JAK3OPRK1 | |
| SCHEMBL28610086 | 0.83 | BTK (0.54) | BTKKMT2AMEN1JAK3OPRK1 | |
| SCHEMBL28610085 | 0.83 | BTK (0.54) | BTKKMT2AMEN1JAK3OPRK1 | |
| SCHEMBL28593044 | 0.80 | SMN1; SMN2 (0.49) | KMT2AMEN1 | |
| SCHEMBL28593047 | 0.80 | SMN1; SMN2 (0.49) | KMT2AMEN1 | |
| SCHEMBL22186385 | 0.80 | KMT2A (0.51) | BTKKMT2AMEN1 | |
| SCHEMBL22164437 | 0.79 | SCN9A (0.45) | BTKTXKITKBMXTEC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164461-A | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2021-07-23 | — | — | CN | claimed |
| CN-113164461-A | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2021-07-23 | — | — | CN | disclosed |