Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | SYK | P43405 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.47 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.41 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.41 |
| ▸ | ITGAL | P20701 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124490 | 1.00 | BTK (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL28610086 | 1.00 | BTK (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL28614144 | 0.85 | JAK3 (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL28605629 | 0.85 | JAK3 (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL28605626 | 0.85 | JAK3 (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL31124509 | 0.85 | JAK3 (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL31124452 | 0.85 | JAK3 (0.54) | BTKJAK3SYKMAP4K4PDE10A | |
| SCHEMBL28610070 | 0.83 | BTK (0.40) | BTKJAK3MEN1KMT2AOPRK1 | |
| SCHEMBL28610069 | 0.83 | BTK (0.40) | BTKJAK3MEN1KMT2AOPRK1 | |
| SCHEMBL31124491 | 0.82 | SYK (0.55) | BTKJAK3SYKMAP4K4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164461-A | Heterocyclic derivatives as Nav1.7 and Nav1.8 blockers | 拉夸里亚创药株式会社 | 2021-07-23 | — | — | CN | disclosed |