SCHEMBL28610691

SCHEMBL28610691

COc1cc(OC)c(Cl)c(N(C(=O)OC(C)(C)C)C(=O)N(c2c[c]ncn2)C2CC2)c1Cl

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 1/20 0.31
▸ FGFR2 P21802 1/20 0.31
▸ FGFR4 P22455 1/20 0.31
▸ FGFR3 P22607 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28609741 0.86 FGFR1 (0.33) FGFR1FGFR2FGFR4FGFR3
SCHEMBL28610616 0.81 FGFR1 (0.38) FGFR1FGFR2FGFR4FGFR3
SCHEMBL28609740 0.81 FGFR1 (0.33) FGFR1FGFR2FGFR4FGFR3
SCHEMBL28607836 0.79 FGFR1 (0.32) FGFR1FGFR2FGFR4FGFR3
SCHEMBL28610615 0.76 EHMT2 (0.31) —
SCHEMBL23889743 0.74 FGFR4 (0.37) FGFR1FGFR2FGFR4FGFR3
SCHEMBL30745811 0.73 FGFR4 (0.37) FGFR1FGFR2FGFR4FGFR3
SCHEMBL16659621 0.73 FGFR4 (0.37) FGFR1FGFR2FGFR4FGFR3
SCHEMBL23665610 0.71 FGFR4 (0.38) FGFR1FGFR2FGFR4FGFR3
SCHEMBL18138353 0.71 FGFR4 (0.34) FGFR1FGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107400092-B Pyrimidine derivative, preparation method thereof and application thereof in medicine 浙江海正药业股份有限公司 2021-08-24 — — CN disclosed
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