Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 8/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NAAA | Q02083 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28454760 | 1.00 | EPHX1 (0.44) | EPHX1EPHX2TSHRACE2GPR84 | |
| SCHEMBL9213061 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL4490677 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL9214846 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL11085237 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL3421946 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL11677493 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL4723686 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL31122641 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR | |
| SCHEMBL2722037 | 0.91 | SHBG (0.41) | EPHX1EPHX2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107344973-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2021-03-16 | — | — | CN | disclosed |
| CN-107344978-B | Catalyst component for olefin polymerization, catalyst system and application thereof | 中国石油化工股份有限公司 | 2020-06-09 | — | — | CN | disclosed |