Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23668822 | 0.81 | PDE7A (0.33) | PDE7A | |
| SCHEMBL28617434 | 0.77 | PDE7A (0.38) | PDE7ASLC6A4AHR | |
| SCHEMBL6605186 | 0.70 | AKR1B1 (0.42) | PDE7AMAP3K14AKR1B1 | |
| SCHEMBL6605188 | 0.70 | AKR1B1 (0.42) | PDE7AMAP3K14AKR1B1 | |
| SCHEMBL6580397 | 0.70 | AKR1B1 (0.42) | PDE7AMAP3K14AKR1B1 | |
| SCHEMBL11345300 | 0.68 | AKR1B1 (0.60) | AKR1B1 | |
| SCHEMBL6760984 | 0.67 | AKR1B1 (0.37) | MAP3K14AKR1B1 | |
| SCHEMBL6605516 | 0.67 | AKR1B1 (0.37) | MAP3K14AKR1B1 | |
| SCHEMBL8793427 | 0.66 | AKR1B1 (0.47) | AKR1B1 | |
| SCHEMBL768845 | 0.64 | MAP3K14 (0.32) | MAP3K14AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113087700-B | Spirocyclic tetrahydroquinazolines | 苏州亚盛药业有限公司 | 2023-03-14 | — | — | CN | disclosed |
| CN-113087700-A | Spirocyclic tetrahydroquinazolines | 苏州亚盛药业有限公司 | 2021-07-09 | — | — | CN | disclosed |