Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 10/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28619694 | 0.92 | CREBBP (0.51) | USP30CREBBPPOLB | |
| SCHEMBL28810229 | 0.81 | USP30 (0.61) | USP30PARP1HDAC4HDAC6 | |
| SCHEMBL994594 | 0.78 | USP30 (0.71) | USP30PARP1HDAC4HDAC6 | |
| SCHEMBL4924196 | 0.78 | USP30 (0.71) | USP30PARP1HDAC4HDAC6 | |
| SCHEMBL4921150 | 0.78 | USP30 (0.71) | USP30PARP1HDAC4HDAC6 | |
| SCHEMBL22131008 | 0.75 | USP30 (0.77) | USP30PARP1HDAC4HDAC6 | |
| SCHEMBL23533928 | 0.74 | USP30 (0.54) | USP30PARP1POLB | |
| SCHEMBL22083665 | 0.74 | USP30 (0.64) | USP30PARP1POLBHDAC4HDAC6 | |
| SCHEMBL18116012 | 0.74 | USP30 (0.74) | USP30HDAC4HDAC6 | |
| SCHEMBL23651222 | 0.74 | USP30 (0.63) | USP30PARP1HDAC4HDAC6DGAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113321640-B | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-06-09 | — | — | CN | disclosed |
| CN-109111427-B | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2023-06-02 | — | — | CN | disclosed |
| CN-113321640-A | Indole compound and application thereof | 中国科学院广州生物医药与健康研究院 | 2021-08-31 | — | — | CN | disclosed |