Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 1/20 | 0.67 |
| ▸ | MAOA | P21397 | 1/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | DRD1 | P21728 | 1/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.67 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.67 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.60 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30485193 | 1.00 | TTR (0.67) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL1675381 | 0.89 | HDAC6 (0.76) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL27215735 | 0.89 | TTR (0.71) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL1675290 | 0.87 | TTR (0.68) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL29784233 | 0.87 | TTR (0.72) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL121966 | 0.87 | TTR (0.72) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL31261529 | 0.86 | TTR (0.67) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL20898024 | 0.86 | HDAC6 (0.74) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL20897612 | 0.86 | MAOA (0.80) | TTRALBMAOACNR1DRD1 | |
| SCHEMBL1675531 | 0.84 | TTR (0.68) | TTRALBMAOACNR1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113277993-B | Synthesis method of Tafamidis and derivatives thereof | 湖南第一师范学院 | 2023-07-21 | — | — | CN | disclosed |
| CN-113277993-A | Synthetic method of Tafamidis and derivatives thereof | 湖南第一师范学院 | 2021-08-20 | — | — | CN | disclosed |