Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 19/20 | 0.57 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286290 | 0.89 | GABRA5 (0.69) | GABRA5 | |
| SCHEMBL286487 | 0.87 | GABRA5 (0.68) | GABRA5GABRG2GABRB3 | |
| SCHEMBL285770 | 0.84 | GABRA5 (0.61) | GABRA5 | |
| SCHEMBL285988 | 0.83 | GABRA5 (0.58) | GABRA5 | |
| SCHEMBL285905 | 0.83 | GABRA5 (0.59) | GABRA5 | |
| SCHEMBL286552 | 0.83 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL286529 | 0.83 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL286180 | 0.82 | GABRA5 (0.72) | GABRA5 | |
| SCHEMBL285771 | 0.82 | GABRA5 (0.62) | GABRA5 | |
| SCHEMBL285909 | 0.82 | GABRA5 (0.74) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163728-B2 | Pyrazoles | HOFFMANN-LA ROCHE INC. (US) | 2012-04-24 | — | — | US | disclosed |
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |