Biguanide

Biguanide

SCHEMBL28618488

N=C(N)NC(=N)N.N=C(N)NC(=O)Nc1ccc(Cl)cc1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 0.58
ALDH1A1 P00352 5/20 0.55
KMT2A Q03164 6/20 0.51
MEN1 O00255 5/20 0.51
CA12 O43570 2/20 0.51
CA1 P00915 2/20 0.51
CA2 P00918 2/20 0.51
CA9 Q16790 2/20 0.51
HTT P42858 4/20 0.50
MAPT P10636 4/20 0.50
RAB9A P51151 4/20 0.50
TSHR P16473 3/20 0.50
LMNA P02545 2/20 0.50
NLRP3 Q96P20 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
EPHX1 P07099 2/20 0.50
NLRP1 Q9C000 1/20 0.50
NPSR1 Q6W5P4 1/20 0.50
ADORA3 P0DMS8 1/20 0.50
CHRM1 P11229 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29827352 0.98 NPC1 (0.60) NPC1ALDH1A1KMT2AMEN1CA12
Triclocarban SCHEMBL28326552 0.84 MEN1 (0.77) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL28597947 0.83 NPC1 (0.70) NPC1ALDH1A1KMT2AMEN1CA12
4-Chlorophenylbiguanide SCHEMBL305068 0.79 NPC1 (0.53) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL10734509 0.79 SMN1; SMN2 (0.61) NPC1ALDH1A1KMT2AMEN1CA12
Bicarbonate SCHEMBL3281891 0.79 NPC1 (0.64) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL11139315 0.79 EPHX1 (0.68) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL4311708 0.79 F2 (0.65) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL1186622 0.78 NPC1 (0.61) NPC1ALDH1A1KMT2AMEN1CA12
SCHEMBL11048619 0.78 MEN1 (0.76) NPC1ALDH1A1KMT2AMEN1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117338615-A Oral care formulations comprising chlorhexidine and arginine or salts thereof 梅达公司 2024-01-05 CN disclosed
CN-113226269-B Oral care formulations comprising chlorhexidine and arginine or salts thereof 梅达公司 2023-11-28 CN disclosed
CN-113226269-A Oral care formulations comprising chlorhexidine and arginine or salts thereof 梅达公司 2021-08-06 CN disclosed