Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 5/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 5/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 8/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.43 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.43 |
| ▸ | ADH1B | P00325 | 1/20 | 0.43 |
| ▸ | ADH1C | P00326 | 1/20 | 0.43 |
| ▸ | ADH1A | P07327 | 1/20 | 0.43 |
| ▸ | ADH4 | P08319 | 1/20 | 0.43 |
| ▸ | ADH7 | P40394 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28663437 | 1.00 | TSHR (0.52) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Bromide SCHEMBL28485545 | 1.00 | TSHR (0.52) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| Bromide SCHEMBL9575940 | 1.00 | TSHR (0.52) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL8871452 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL8871137 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL4538493 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL3284743 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL4540119 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL9575912 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 | |
| SCHEMBL8871024 | 0.98 | TSHR (0.55) | TSHRALDH1A1S1PR2S1PR4S1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114989509-B | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-10-18 | — | — | CN | claimed |
| CN-114989509-A | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-09-02 | — | — | CN | claimed |
| CN-113248839-B | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-113248839-A | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2021-08-13 | — | — | CN | claimed |
| CN-114989509-B | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-114989509-A | Environment-friendly oil-resistant high-strength NBR rubber sheet and preparation method thereof | 山东穆柯传感器有限公司 | 2022-09-02 | — | — | CN | disclosed |
| CN-113248839-B | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2022-03-18 | — | — | CN | disclosed |
| CN-113248839-A | Reinforced TPV (thermoplastic vulcanizate) material for MDI (diphenylmethane diisocyanate) foaming bonding and preparation method thereof | 会通新材料股份有限公司 | 2021-08-13 | — | — | CN | disclosed |