Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 15/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4341222 | 0.91 | ABL1 (0.34) | ABL1P2RX4ANO1MAPK1RPS6KA1 | |
| SCHEMBL209633 | 0.91 | ABL1 (0.34) | ABL1P2RX4ANO1 | |
| SCHEMBL2839842 | 0.90 | ABL1 (0.33) | ABL1P2RX4 | |
| SCHEMBL212529 | 0.90 | ABL1 (0.33) | ABL1P2RX4 | |
| SCHEMBL213942 | 0.89 | ABL1 (0.34) | ABL1P2RX4 | |
| SCHEMBL210583 | 0.89 | ABL1 (0.33) | ABL1P2RX4 | |
| SCHEMBL211437 | 0.88 | CARM1 (0.35) | ABL1P2RX4ANO1 | |
| SCHEMBL253436 | 0.88 | ABL1 (0.32) | ABL1P2RX4 | |
| SCHEMBL210176 | 0.88 | ABL1 (0.33) | ABL1P2RX4EGFRMAPK1 | |
| SCHEMBL212238 | 0.87 | P2RX4 (0.32) | ABL1P2RX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195328-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | Cytokinetics, Incorporated (US) | 2010-06-16 | — | — | EP | disclosed |
| WO-2009023193-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | CYTOKINETICS, INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |