Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 3/20 | 0.38 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.38 |
| ▸ | ITGAV | P06756 | 2/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.35 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.35 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrogen Peroxide SCHEMBL9062435 | 0.88 | MAP3K14 (0.46) | ITGB1ITGA5ITGB3ITGAVITGB2 | |
| SCHEMBL168361 | 0.83 | — | — | |
| SCHEMBL48364 | 0.83 | — | — | |
| SCHEMBL3650532 | 0.83 | — | — | |
| Hydrochloric Acid SCHEMBL17873779 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL19359380 | 0.81 | — | — | |
| Water SCHEMBL5331043 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL19359427 | 0.81 | — | — | |
| Succinic Acid SCHEMBL28474102 | 0.78 | ITGB1 (0.39) | ITGB1ITGA5ITGB3ITGAVITGB2 | |
| Succinic Acid SCHEMBL7441808 | 0.77 | CRBN (0.40) | ITGB1ITGA5ITGB3ITGAVITGB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113350520-A | Hydrogen sulfide controlled-release brain targeting nano system for protecting nervous system after cardiac arrest and preparation method thereof | 复旦大学附属华山医院 | 2021-09-07 | — | — | CN | claimed |
| CN-112250678-B | Washing-free brain glioma image fluorescent molecular probe and preparation method and application thereof | 中南大学 | 2022-04-05 | — | — | CN | disclosed |