Tetrahydrofuran

Tetrahydrofuran

SCHEMBL28620649

C1CCOC1.NC(=O)CBr

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.43
ALDH1A1 P00352 2/20 0.42
GSK3B P49841 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
TSHR P16473 1/20 0.32
GLA P06280 2/20 0.31
TP53 P04637 2/20 0.30
TRPA1 O75762 1/20 0.30
GMNN O75496 1/20 0.30
USP2 O75604 1/20 0.30
LMNA P02545 1/20 0.30
CYP1A2 P05177 1/20 0.30
POLB P06746 1/20 0.30
CYP3A4 P08684 1/20 0.30
CYP2C9 P11712 1/20 0.30
HPGD P15428 1/20 0.30
ALOX15 P16050 1/20 0.30
CYP2C19 P33261 1/20 0.30
THPO P40225 1/20 0.30
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tetrahydrofuran SCHEMBL27547612 0.80
Tetrahydrofuran SCHEMBL28130259 0.79 KDM4E (0.43) KDM4EALDH1A1L3MBTL1TSHRGLA
Tetrahydrofuran SCHEMBL29092140 0.79 ALDH1A1 (0.42) ALDH1A1GSK3BTSHRGLATP53
Tetrahydrofuran SCHEMBL27541147 0.77
Tetrahydrofuran SCHEMBL10621146 0.77 ALDH1A1 (0.53) KDM4EALDH1A1TSHRGLATP53
SCHEMBL56502 0.76
Butyramide SCHEMBL28259400 0.75 KDM4E (0.40) KDM4EALDH1A1L3MBTL1TSHRTP53
Carbamic Acid SCHEMBL21066034 0.75 ALDH1A1 (0.50) KDM4EALDH1A1L3MBTL1GLATP53
Tetrahydrofuran SCHEMBL27311071 0.75 ALDH1A1 (0.50) KDM4EALDH1A1GLATP53LMNA
Carbamic Acid SCHEMBL2726104 0.75 ALDH1A1 (0.50) KDM4EALDH1A1L3MBTL1GLATP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113248367-B Method for realizing continuous production of acyl chloride compound by catalysis of immobilized organic base 东南大学 2022-04-26 CN disclosed
CN-113248367-A Method for realizing continuous production of acyl chloride compound by catalysis of immobilized organic base 东南大学 2021-08-13 CN disclosed