Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 10/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 10/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 10/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 5/20 | 0.43 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.36 |
| ▸ | SLC6A11 | P48066 | 2/20 | 0.36 |
| ▸ | SLC6A13 | Q9NSD5 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13604607 | 0.86 | S1PR4 (0.36) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| SCHEMBL27869789 | 0.83 | SLC6A1 (0.42) | S1PR4S1PR1S1PR5S1PR3SLC6A1 | |
| SCHEMBL27852997 | 0.82 | S1PR4 (0.42) | S1PR4S1PR1S1PR5S1PR3SLC6A1 | |
| SCHEMBL27869829 | 0.82 | S1PR4 (0.42) | S1PR4S1PR1S1PR5S1PR3SLC6A1 | |
| SCHEMBL4493249 | 0.82 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| SCHEMBL2493402 | 0.82 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| SCHEMBL2861143 | 0.82 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| SCHEMBL21820688 | 0.82 | PSEN1 (0.45) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| Hydrochloric Acid SCHEMBL2874986 | 0.81 | PSEN1 (0.44) | S1PR4S1PR1S1PR5S1PR3DGAT1 | |
| Hydrochloric Acid SCHEMBL28794751 | 0.81 | GRIK2 (0.40) | S1PR4S1PR1S1PR5S1PR3SLC6A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805141-B1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2010-01-20 | — | — | EP | disclosed |
| EP-1805141-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LTD. (GB) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006043064-A1 | PIPERIDINES AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-04-27 | — | — | WO | disclosed |