Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.64 |
| ▸ | THRA | P10827 | 9/20 | 0.64 |
| ▸ | THRB | P10828 | 9/20 | 0.64 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.64 |
| ▸ | ASPH | Q12797 | 1/20 | 0.64 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.64 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.64 |
| ▸ | EGLN2 | Q96KS0 | 7/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31296198 | 1.00 | EGLN1 (0.64) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523175 | 0.94 | EGLN1 (0.62) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL31296196 | 0.94 | EGLN1 (0.62) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL20039923 | 0.92 | THRA (0.67) | EGLN1THRATHRBBBOX1SLC6A2 | |
| Hydrochloric Acid SCHEMBL22441916 | 0.91 | THRA (0.66) | EGLN1THRATHRBBBOX1SLC6A2 | |
| Sulfuric Acid SCHEMBL22441927 | 0.88 | THRA (0.62) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL28488469 | 0.87 | EGLN1 (0.64) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL523125 | 0.86 | EGLN1 (0.61) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL31267308 | 0.85 | EGLN1 (0.70) | EGLN1THRATHRBBBOX1SLC6A2 | |
| SCHEMBL29046746 | 0.85 | EGLN1 (0.67) | EGLN1THRATHRBBBOX1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116803986-B | Synthesis method of roflumilast intermediate | 江苏海洋大学 | 2024-02-06 | — | — | CN | disclosed |
| CN-116803986-A | Synthesis method of roflumilast intermediate | 江苏海洋大学 | 2023-09-26 | — | — | CN | disclosed |
| CN-113336667-B | Method suitable for industrial production of intermediate of roxasistat | 南京正济医药研究有限公司 | 2022-12-13 | — | — | CN | disclosed |
| CN-113336667-A | Method suitable for industrial production of intermediate of roxasistat | 南京正济医药研究有限公司 | 2021-09-03 | — | — | CN | disclosed |