Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.52 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 2/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29870666 | 1.00 | CCNE2 (0.55) | CCNE2CCNE1CDK2APPMAPT | |
| SCHEMBL28921675 | 0.89 | CCNE2 (0.49) | CCNE2CCNE1CDK2APPMAPT | |
| SCHEMBL29871205 | 0.89 | EPAS1 (0.62) | CCNE2CCNE1CDK2APPMAPT | |
| SCHEMBL28921677 | 0.89 | EPAS1 (0.62) | CCNE2CCNE1CDK2APPMAPT | |
| SCHEMBL29871428 | 0.84 | EPAS1 (0.52) | APPMAPTLMNAEPAS1ACHE | |
| SCHEMBL28624524 | 0.84 | EPAS1 (0.52) | APPMAPTLMNAEPAS1ACHE | |
| SCHEMBL28616350 | 0.83 | APP (0.54) | APPEPAS1ACHEMAPK8CDC7 | |
| SCHEMBL28613603 | 0.83 | ACHE (0.44) | APPMAPTTP53LMNAEPAS1 | |
| SCHEMBL29870797 | 0.83 | ACHE (0.44) | CCNE2CCNE1CDK2MAPTTP53 | |
| SCHEMBL29871039 | 0.83 | APP (0.54) | APPEPAS1ACHEMAPK8CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292510-B | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2022-08-26 | — | — | CN | disclosed |
| CN-113292510-A | Benzisothiazole compound for inhibiting hypoxia inducible factor 2 activity, preparation method and application thereof | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |