Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.30 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
| ▸ | NOS2 | P35228 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27923441 | 0.85 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL28621836 | 0.85 | SLC6A2 (0.34) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL28073278 | 0.84 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL28073211 | 0.84 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL1867707 | 0.83 | CA2 (0.41) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL27893509 | 0.80 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3CA2KCNH2 | |
| SCHEMBL27893507 | 0.79 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL27935392 | 0.78 | CA12 (0.33) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL28073280 | 0.78 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A3CA12CA1 | |
| SCHEMBL27893574 | 0.77 | TACR1 (0.39) | SLC6A2SLC6A4SLC6A3CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108175749-B | Melt-extruded solid dispersions containing apoptosis-inducing agents | 艾伯维爱尔兰无限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-103167867-B | Solid dispersion containing apoptosis-inducing medicament | ABBVIE 公司 | 2016-12-21 | — | — | CN | disclosed |
| CN-103153993-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBVIE INC. (BS) | 2016-06-01 | — | — | CN | disclosed |
| CN-103282025-A | Melt-extruded solid dispersions containing apoptosis-inducing agents | ABBVIE INC | 2013-09-04 | — | — | CN | disclosed |
| CN-103167867-A | Solid dispersions containing an apoptosis-inducing agent | ABBOTT LAB | 2013-06-19 | — | — | CN | disclosed |
| CN-103153993-A | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBOTT LAB | 2013-06-12 | — | — | CN | disclosed |
| CN-102947285-A | Sulfonamide derivatives as BCL-2-selective apoptosis inducers for the treatment of cancer and immune diseases | ABBOTT LAB | 2013-02-27 | — | — | CN | disclosed |