Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | ELANE | P08246 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2987983 | 0.84 | NR4A2 (0.65) | SMN1; SMN2NPC1RAB9AMAOBKMT2A | |
| SCHEMBL2350906 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1RAB9AELANEMAOB | |
| SCHEMBL23671644 | 0.83 | MAOB (0.47) | SMN1; SMN2NPC1RAB9AMAOBKMT2A | |
| SCHEMBL4220649 | 0.83 | NR4A2 (0.63) | SMN1; SMN2NPC1RAB9AMAOBKMT2A | |
| SCHEMBL28628955 | 0.82 | SRC (0.48) | SMN1; SMN2NPC1RAB9AELANEMAOB | |
| SCHEMBL9568480 | 0.82 | TSHR (0.57) | MAOBKMT2AMEN1ALDH1A1TSHR | |
| Silver SCHEMBL4220651 | 0.81 | TSHR (0.49) | SMN1; SMN2NPC1RAB9AMAOBTSHR | |
| SCHEMBL4231246 | 0.81 | SRD5A2 (0.55) | ELANEMAOBGAATSHRHTT | |
| SCHEMBL21419139 | 0.80 | TSHR (0.51) | SMN1; SMN2NPC1RAB9AMAOBALDH1A1 | |
| SCHEMBL4220394 | 0.79 | SRD5A2 (0.54) | ELANEMAOBGAATSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116283647-A | Prodrug modulators that integrate stress pathways | 卡里科生命科学有限责任公司 | 2023-06-23 | — | — | CN | disclosed |
| CN-113423685-B | Prodrug modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-113423685-A | Prodrug modulators of integrated stress pathways | 卡里科生命科学有限责任公司 | 2021-09-21 | — | — | CN | disclosed |