Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.59 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28381883 | 0.93 | EGFR (0.57) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL28839312 | 0.92 | EGFR (0.55) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL28840165 | 0.92 | EGFR (0.55) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL32671769 | 0.90 | MKNK1 (0.65) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL29555980 | 0.90 | MKNK1 (0.65) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL14660648 | 0.90 | MKNK1 (0.65) | EGFRMKNK1MKNK2FLT3JAK2 | |
| Hydrochloric Acid SCHEMBL31218386 | 0.90 | MKNK1 (0.64) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL17683312 | 0.89 | EGFR (0.55) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL28382476 | 0.89 | EGFR (0.56) | EGFRMKNK1MKNK2FLT3JAK2 | |
| SCHEMBL30459800 | 0.89 | EGFR (0.55) | EGFRMKNK1MKNK2FLT3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107793413-B | Pyrimidine heterocyclic compound and preparation method and application thereof | 上海科州药物研发有限公司 | 2021-09-28 | — | — | CN | disclosed |