Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FLT4 | P35916 | 1/20 | 0.48 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17683312 | 1.00 | EGFR (0.55) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL14660648 | 0.92 | MKNK1 (0.65) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL29555980 | 0.92 | MKNK1 (0.65) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL32671769 | 0.92 | MKNK1 (0.65) | EGFRMKNK2MKNK1JAK2ROS1 | |
| Hydrochloric Acid SCHEMBL31218386 | 0.91 | MKNK1 (0.64) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL28382476 | 0.90 | EGFR (0.56) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL30460067 | 0.89 | EGFR (0.54) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL17683074 | 0.89 | EGFR (0.54) | EGFRMKNK2MKNK1JAK2ROS1 | |
| SCHEMBL28626639 | 0.89 | MKNK2 (0.51) | EGFRMKNK2MKNK1 | |
| SCHEMBL28626645 | 0.89 | EGFR (0.59) | EGFRMKNK2MKNK1JAK2ROS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117402143-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-117069700-A | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-111187221-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-26 | — | — | CN | disclosed |
| CN-111171000-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-111170999-B | EGFR inhibitor and preparation and application thereof | 上海翰森生物医药科技有限公司 | 2023-06-30 | — | — | CN | disclosed |