Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 19/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | RPA1 | P27694 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL286362 | 0.89 | GABRA5 (0.48) | GABRA5ALPL | |
| SCHEMBL285835 | 0.83 | GABRA5 (0.43) | GABRA5 | |
| SCHEMBL1779461 | 0.81 | GABRA5 (0.52) | GABRA5 | |
| SCHEMBL2926043 | 0.80 | GABRA5 (0.65) | GABRA5 | |
| SCHEMBL286487 | 0.80 | GABRA5 (0.68) | GABRA5 | |
| SCHEMBL27865421 | 0.74 | GABRA5 (0.55) | GABRA5 | |
| SCHEMBL2933362 | 0.73 | GABRA5 (0.68) | GABRA5 | |
| SCHEMBL1776175 | 0.73 | GABRA5 (0.48) | GABRA5 | |
| SCHEMBL2926693 | 0.72 | GABRA5 (0.56) | GABRA5 | |
| SCHEMBL1776863 | 0.72 | GABRA5 (0.48) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427455-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127975-A1 | ISOXAZOLE-PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2010-11-11 | — | — | WO | disclosed |