Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28623297 | 0.86 | IKBKB (0.47) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL28623302 | 0.82 | ALDH1A1 (0.45) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL9586961 | 0.77 | KDM4E (1.00) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL10999906 | 0.74 | MAPT (0.55) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL2466877 | 0.73 | KDM4E (0.54) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL495789 | 0.72 | KDM4E (0.72) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL1918075 | 0.72 | KDM4E (0.53) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL30481035 | 0.72 | KDM4E (0.53) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL2464043 | 0.71 | KDM4E (0.56) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 | |
| SCHEMBL1917389 | 0.71 | KDM4E (0.52) | KDM4ESMN1; SMN2PKMALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118108744-A | Isothiazolopyrimidinone compounds, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2024-05-31 | — | — | CN | disclosed |
| CN-113087724-B | Isothiazolopyrimidinone compounds, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2024-01-19 | — | — | CN | disclosed |
| CN-113087724-A | Isothiazolopyrimidinones, pharmaceutical compositions containing the same and uses thereof | 四川科伦博泰生物医药股份有限公司 | 2021-07-09 | — | — | CN | disclosed |