Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28632463 | 0.83 | HTT (0.41) | HTTMAPTLMNAPOLBMEN1 | |
| SCHEMBL22165348 | 0.80 | SMN1; SMN2 (0.46) | HTTMAPTLMNAPOLBMEN1 | |
| SCHEMBL23978180 | 0.68 | JAK2 (0.33) | — | |
| SCHEMBL4712339 | 0.67 | HTT (0.76) | HTTMAPTLMNAPOLBSMN1; SMN2 | |
| SCHEMBL30879292 | 0.65 | GAA (0.59) | HTTMAPTLMNAMEN1KMT2A | |
| SCHEMBL16824948 | 0.65 | KDM4E (0.54) | HTTPOLBMEN1KMT2AALDH1A1 | |
| SCHEMBL22165446 | 0.65 | HTT (0.46) | HTTMAPTPOLBMEN1KMT2A | |
| SCHEMBL3970506 | 0.64 | POLB (0.59) | LMNAPOLBALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL22178978 | 0.64 | SMN1; SMN2 (0.56) | HTTMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL30879308 | 0.64 | MAPT (0.80) | HTTMAPTLMNAPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113474347-A | AZA heterobicyclic inhibitors of MAT2A and methods for treating cancer | 法国施维雅药厂 | 2021-10-01 | — | — | CN | disclosed |