Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | KCNA3 | P22001 | 14/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879950 | 0.93 | MEN1 (0.61) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL5350627 | 0.89 | KCNA3 (0.64) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL5351670 | 0.89 | KCNA3 (0.64) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2860301 | 0.86 | MEN1 (0.56) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2870241 | 0.86 | KCNA3 (0.53) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2856024 | 0.84 | KCNA3 (0.53) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2862893 | 0.84 | MEN1 (0.52) | MEN1KMT2AKCNA3P2RX7ALDH1A1 | |
| SCHEMBL2860755 | 0.84 | MEN1 (0.62) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2867546 | 0.84 | KCNA3 (0.52) | MEN1KMT2AKCNA3ALDH1A1 | |
| SCHEMBL2861390 | 0.83 | MEN1 (0.48) | MEN1KMT2AKCNA3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253328-A1 | Cycloalkyl inhibitors of potassium channel function | Bristol-Myers Squibb Company (US) | 2010-11-24 | — | — | EP | disclosed |
| US-20070142333-A1 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | BRISTOL-MYERS SQUIBB COMPANY | 2007-06-21 | — | — | US | disclosed |
| US-7202253-B2 | Cycloalkyl inhibitors of potassium channel function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-04-10 | — | — | US | disclosed |
| US-20050234106-A1 | Cycloalkyl inhibitors of potassium channel function | LLOYD JOHN | 2005-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050234106-A1 | Cycloalkyl inhibitors of potassium channel function | KCNJ2, KCNN3, KCNQ5 | MEN1 4430/4885KMT2A 1396/4885KCNA3 18/4885 |
| US-20070142333-A1 | CYCLOALKYL INHIBITORS OF POTASSIUM CHANNEL FUNCTION | KCNJ2, KCNN3, KCNQ5 | MEN1 4430/4885KMT2A 1396/4885KCNA3 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.