SCHEMBL28629587

SCHEMBL28629587

[CH2]C(C)Oc1ccc(C=O)cc1

nearest known ligand 0.70

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A3 P47895 1/20 0.70
ALDH1A1 P00352 7/20 0.54
CYP2A6 P11509 3/20 0.54
DRD1 P21728 1/20 0.53
TYR P14679 1/20 0.48
STS P08842 1/20 0.42
LMNA P02545 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
KDM4E B2RXH2 2/20 0.40
PARP10 Q53GL7 1/20 0.39
PARP3 Q9Y6F1 1/20 0.39
KMT2A Q03164 1/20 0.39
CYP2A13 Q16696 1/20 0.39
HSD17B10 Q99714 1/20 0.38
ALDH5A1 P51649 1/20 0.38
ABAT P80404 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL384361 0.83 ALDH1A3 (1.00) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL14016002 0.83 ALDH1A3 (0.76) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL1177478 0.79 ALDH1A3 (0.70) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL28432822 0.79 ALDH1A3 (0.70) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL8727778 0.79 ALDH1A3 (0.70) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL10572046 0.79 ALDH1A3 (0.70) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL3423566 0.78 ALDH1A3 (0.88) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL4744709 0.78 ALDH1A3 (0.88) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL16353393 0.76 ALDH1A3 (0.66) ALDH1A3ALDH1A1CYP2A6DRD1TYR
SCHEMBL1858792 0.76 ALDH1A3 (0.66) ALDH1A3ALDH1A1CYP2A6DRD1TYR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113454086-A Imidazo [2,1-F ] [1,2,4] triazin-4-amine derivatives as TLR7 agonists 百济神州有限公司 2021-09-28 CN disclosed