Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pyridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridazine SCHEMBL2162869 | 1.00 | FFAR3 (0.47) | FFAR3LCKFYNALDH1A1NAPRT | |
| Pyridazine SCHEMBL30071072 | 1.00 | FFAR3 (0.47) | FFAR3LCKFYNALDH1A1NAPRT | |
| Pyridazine SCHEMBL25427017 | 0.97 | FFAR3 (0.44) | FFAR3LCKFYNALDH1A1NAPRT | |
| Pyridazine SCHEMBL17962960 | 0.89 | FFAR3 (0.37) | FFAR3LCKFYNALDH1A1NAPRT | |
| Pyridazine SCHEMBL7889331 | 0.86 | CA1 (0.39) | ALDH1A1NAPRTLMNAP4HTML3MBTL1 | |
| Oxalic Acid SCHEMBL27823009 | 0.83 | NAPRT (0.36) | NAPRTLMNAP4HTML3MBTL1HCAR2 | |
| Benzene SCHEMBL10625833 | 0.82 | FFAR3 (0.70) | FFAR3LCKFYNALDH1A1NAPRT | |
| Pyridazine SCHEMBL27653386 | 0.82 | — | — | |
| Pyridazine SCHEMBL25427016 | 0.81 | CA1 (0.53) | ALDH1A1L3MBTL1TDP1 | |
| Pyridine SCHEMBL28350653 | 0.81 | NAPRT (0.45) | FFAR3LCKFYNALDH1A1NAPRT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110455732-B | Biological sample treatment method, ferrous ion or total ferric ion determination method of biological sample and detection kit | 吉林大学 | 2021-09-28 | — | — | CN | disclosed |