Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pyridazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxalic Acid SCHEMBL27823009 | 0.89 | NAPRT (0.36) | NAPRTTDP1HCAR2TSHRLMNA | |
| Oxalic Acid SCHEMBL27828347 | 0.86 | NAPRT (0.35) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL9257443 | 0.86 | NAPRT (0.35) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL2162869 | 0.86 | FFAR3 (0.47) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL28630845 | 0.86 | FFAR3 (0.47) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL30071072 | 0.86 | FFAR3 (0.47) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL5216865 | 0.86 | NAPRT (0.35) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL20893379 | 0.86 | ACHE (0.47) | NAPRTTDP1HCAR2TSHRLMNA | |
| Pyridazine SCHEMBL25427017 | 0.83 | FFAR3 (0.44) | NAPRTTDP1HCAR2TSHRLMNA | |
| Benzene SCHEMBL250829 | 0.83 | TSHR (0.50) | NAPRTTDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0621788-B1 | HEMOREGULATORY PEPTIDES | SMITHKLINE BEECHAM CORP (US) | 2001-05-30 | — | — | EP | claimed |
| EP-0725651-B1 | HEMOREGULATORY PEPTIDES | SMITHKLINE BEECHAM CORP (US) | 1999-08-11 | — | — | EP | claimed |
| EP-2554539-B1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | UNIVERSITÄT POTSDAM (DE) | 2014-12-10 | — | — | EP | disclosed |
| EP-2554539-A1 | Method for producing gamma-spirolactams from cyclic unsaturated carboxylic acids | Universität Potsdam (DE) | 2013-02-06 | — | — | EP | disclosed |