Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.65 |
| ▸ | APLNR | P35414 | 1/20 | 0.65 |
| ▸ | GLP1R | P43220 | 1/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.65 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 7/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2867186 | 0.90 | NPSR1 (0.71) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2856713 | 0.89 | NPSR1 (0.74) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2864540 | 0.88 | NPSR1 (0.62) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2863650 | 0.86 | NPSR1 (0.67) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2863545 | 0.85 | NPSR1 (0.58) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2861754 | 0.84 | NPSR1 (0.82) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2861974 | 0.84 | NPSR1 (0.66) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2864823 | 0.83 | NPSR1 (0.65) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2861928 | 0.83 | NPSR1 (0.65) | NPSR1ADRB2APLNRGLP1RFFAR4 | |
| SCHEMBL2870721 | 0.83 | NPSR1 (0.65) | NPSR1ADRB2APLNRGLP1RFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795267-B2 | Bicyclic piperazine compound having TGR23 antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-14 | — | — | US | disclosed |
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-1661898-A1 | BICYCLIC PIPERAZINE COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2006-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070072865-A1 | Bicyclic piperazine compound and use thereof | GPR3, FFAR3, LPAR3 | NPSR1 211/4885ADRB2 449/4885APLNR 136/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.