SCHEMBL28633357

SCHEMBL28633357

CC(CCN(C)C)NC(=O)c1ccc2c(-c3ccc(C(F)(F)F)cc3)cccc2c1

nearest known ligand 0.48

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.48
UTS2R Q9UKP6 14/20 0.47
HDAC4 P56524 3/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
MTTP P55157 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28633355 1.00 LMNA (0.48) LMNAUTS2RHDAC4NPC1RAB9A
SCHEMBL23795925 0.90 HDAC4 (0.53) LMNAHDAC4NPC1RAB9A
SCHEMBL23796124 0.90 HDAC4 (0.53) LMNAHDAC4NPC1RAB9A
SCHEMBL23795923 0.90 HDAC4 (0.53) LMNAHDAC4NPC1RAB9A
SCHEMBL23796438 0.90 LMNA (0.47) LMNAHDAC4NPC1RAB9AMTTP
SCHEMBL28922738 0.90 LMNA (0.47) LMNAHDAC4NPC1RAB9AMTTP
SCHEMBL28624302 0.90 LMNA (0.47) LMNAHDAC4NPC1RAB9AMTTP
SCHEMBL28640207 0.88 LMNA (0.45) LMNAHDAC4NPC1RAB9AMTTP
SCHEMBL23796399 0.88 LMNA (0.45) LMNAHDAC4NPC1RAB9AMTTP
SCHEMBL28622798 0.88 LMNA (0.45) LMNAHDAC4NPC1RAB9AMTTP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113302175-A Bicyclic compounds 维瓦斯治疗公司 2021-08-24 CN disclosed