SCHEMBL28633828

SCHEMBL28633828

Cc1ccc2c(n1)C(=O)C(Cl)=C(Cl)C2=O

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NSD2 O96028 6/20 0.51
DNMT1 P26358 3/20 0.51
G6PD P11413 2/20 0.51
S100A4 P26447 4/20 0.50
CDC25B P30305 4/20 0.48
IDO1 P14902 1/20 0.41
DNMT3L Q9UJW3 1/20 0.41
DNMT3A Q9Y6K1 1/20 0.41
TDP2 O95551 1/20 0.37
CYP2C19 P33261 1/20 0.36
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
CES1 P23141 1/20 0.34
CCR1 P32246 1/20 0.33
RAB9A P51151 1/20 0.33
CCR5 P51681 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31316976 1.00 NSD2 (0.51) NSD2DNMT1G6PDS100A4CDC25B
SCHEMBL5925146 0.85 NSD2 (0.62) NSD2DNMT1G6PDS100A4CDC25B
SCHEMBL3722975 0.81 S100A4 (0.59) NSD2DNMT1G6PDS100A4TDP2
Water SCHEMBL10372295 0.79 NSD2 (0.58) NSD2DNMT1G6PDS100A4TDP2
SCHEMBL24452738 0.76 CDC25B (0.48) NSD2DNMT1G6PDS100A4CDC25B
SCHEMBL7694867 0.76 NSD2 (0.70) NSD2DNMT1G6PDS100A4CDC25B
SCHEMBL28498561 0.72 MAOB (0.55) NSD2DNMT1G6PDS100A4CDC25B
SCHEMBL13168839 0.72 NSD2 (0.47) NSD2DNMT1G6PDS100A4CYP2C19
SCHEMBL28987151 0.71 CDC25B (0.47) DNMT1S100A4CDC25BIDO1DNMT3L
SCHEMBL5925143 0.68 NSD2 (1.00) NSD2DNMT1G6PDS100A4CDC25B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116003423-A Method for synthesizing spiro compound by photocatalysis 广西大学 2023-04-25 CN disclosed
CN-110423242-B 6, 7-dichloroquinoline-5, 8-diketone derivative transition metal complex and synthetic method and application thereof 桂林师范高等专科学校 2021-09-14 CN disclosed