Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.77 |
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 0.68 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523652 | 0.88 | TDP1 (0.88) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL20846409 | 0.81 | LPAR3 (1.00) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL522502 | 0.80 | TDP1 (0.64) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL1656856 | 0.80 | TDP1 (0.69) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL521888 | 0.80 | TDP1 (0.73) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL1657100 | 0.80 | TDP1 (0.72) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL13187733 | 0.76 | TDP1 (0.77) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL15271754 | 0.76 | KMT2A (0.78) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL521864 | 0.75 | LPAR3 (0.66) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A | |
| SCHEMBL1655994 | 0.75 | LPAR3 (0.65) | TDP1LPAR3LPAR1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113292494-A | Isoquinoline carboxylic acid compound and preparation method and application thereof | 江苏苏中药业集团股份有限公司 | 2021-08-24 | — | — | CN | disclosed |