Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 2/20 | 1.00 |
| ▸ | LPAR1 | Q92633 | 1/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.86 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523652 | 0.90 | TDP1 (0.88) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL1656185 | 0.87 | LPAR3 (0.76) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL124512 | 0.85 | LPAR1 (0.73) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL1657100 | 0.84 | TDP1 (0.72) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL13187733 | 0.84 | TDP1 (0.77) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL15271754 | 0.83 | KMT2A (0.78) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL1656856 | 0.82 | TDP1 (0.69) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL24909290 | 0.81 | LPAR3 (0.68) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL28634112 | 0.81 | TDP1 (0.77) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 | |
| SCHEMBL521864 | 0.80 | LPAR3 (0.66) | LPAR3LPAR1TDP1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210139423-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | THE TEXAS A&M UNIVERSITY SYSTEM | 2021-05-13 | — | — | US | disclosed |
| US-20190092723-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2019-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210139423-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | ORAI1, SARAF, CACNA1C | LPAR3 617/4885LPAR1 662/4885TDP1 3428/4885 |
| US-20190092723-A1 | CHEMICAL MODULATORS OF STORE-OPERATED CALCIUM CHANNELS AND THEIR THERAPEUTIC APPLICATIONS | ORAI1, SARAF, CACNA1C | LPAR3 617/4885LPAR1 662/4885TDP1 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.