Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 5/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31487828 | 0.83 | EPHB3 (0.54) | EPHB3MAPK14ALOX5PIM1PIM2 | |
| SCHEMBL23087251 | 0.80 | PRMT5 (0.47) | EPHB3CYP3A4GRM4 | |
| SCHEMBL23087176 | 0.80 | PRMT5 (0.46) | EPHB3MAOBNPC1RAB9A | |
| SCHEMBL22650738 | 0.78 | EPHB3 (0.60) | EPHB3MAPK14ALOX5PIM1PIM2 | |
| SCHEMBL3611334 | 0.78 | EPHB3 (0.66) | EPHB3MAPK14MAOBNR4A2MEN1 | |
| SCHEMBL3614231 | 0.76 | EPHB3 (0.66) | EPHB3MAPK14MAOBNR4A2MEN1 | |
| SCHEMBL29548854 | 0.74 | EPHB3 (0.48) | EPHB3MAPK14MAOBNPC1RAB9A | |
| SCHEMBL29548130 | 0.74 | EPHB3 (0.46) | EPHB3MAPK14ALOX5MEN1KMT2A | |
| SCHEMBL29548553 | 0.74 | EPHB3 (0.48) | EPHB3ALOX5NPC1RAB9ACYP3A4 | |
| SCHEMBL31487829 | 0.74 | MAPK14 (0.49) | EPHB3MAPK14ALOX5MAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022070288-A1 | NITROGEN-CONTAINING BICYCLIC COMPOUND | 旭化成ファーマ株式会社 | 2022-04-07 | — | — | WO | disclosed |
| CN-113336751-A | High-efficiency salt-induced kinase inhibitor and preparation method thereof | 南京谷睿生物科技有限公司 | 2021-09-03 | — | — | CN | disclosed |