Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 4/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3611334 | 0.88 | EPHB3 (0.66) | EPHB3MAOBMAPK14NR4A2ALKBH1 | |
| SCHEMBL3614231 | 0.83 | EPHB3 (0.66) | EPHB3MAOBMAPK14NR4A2ALKBH1 | |
| SCHEMBL28634245 | 0.78 | EPHB3 (0.56) | EPHB3MAOBMAPK14NR4A2MEN1 | |
| SCHEMBL31487828 | 0.78 | EPHB3 (0.54) | EPHB3MAOBMAPK14NR4A2MEN1 | |
| SCHEMBL17311761 | 0.75 | EPHB3 (0.57) | EPHB3NR4A2ALKBH1MEN1KMT2A | |
| SCHEMBL2878118 | 0.75 | EPHB3 (1.00) | EPHB3MEN1KMT2AROCK1NPC1 | |
| SCHEMBL15882227 | 0.74 | EPHB3 (0.56) | EPHB3ROCK1RAB9A | |
| SCHEMBL383126 | 0.72 | MAOB (0.60) | MAOBNR4A2NPC1RAB9AALOX5 | |
| SCHEMBL10063394 | 0.72 | MAOB (0.73) | MAOBALOX5 | |
| SCHEMBL29548553 | 0.71 | EPHB3 (0.48) | EPHB3NPC1RAB9AALOX5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146647-B1 | CDK INHIBITORS | GENENTECH INC (US) | 2026-04-15 | — | — | EP | disclosed |
| US-20250325544-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-10-23 | — | — | US | disclosed |
| US-20250281487-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-11 | — | — | US | disclosed |
| US-20250275972-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-04 | — | — | US | disclosed |
| US-20250275971-A1 | CDK INHIBITORS | GENENTECH, INC. (US) | 2025-09-04 | — | — | US | disclosed |
| CN-120040446-A | CDK inhibitors | 基因泰克公司 | 2025-05-27 | — | — | CN | disclosed |
| US-12285429-B2 | CDK inhibitors | GENENTECH, INC. (US) | 2025-04-29 | — | — | US | disclosed |
| US-20250064806-A1 | CDK INHIBITORS | GENENTECH, INC. | 2025-02-27 | — | — | US | disclosed |
| CN-118406049-A | CDK inhibitors | 锐格药业公司 | 2024-07-30 | — | — | CN | disclosed |
| US-20240066031-A1 | CDK INHIBITORS | GENENTECH, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20240066031-A1 | CDK INHIBITORS | GENENTECH, INC. | 2024-02-29 | — | — | US | disclosed |
| US-20240033264-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2024-02-01 | — | — | US | disclosed |
| US-20230174512-A1 | CDK INHIBITORS | GENENTECH, INC. | 2023-06-08 | — | — | US | disclosed |
| US-20230174512-A1 | CDK INHIBITORS | GENENTECH, INC. | 2023-06-08 | — | — | US | disclosed |
| US-20220296595-A1 | CDK INHIBITORS | GENENTECH, INC. | 2022-09-22 | — | — | US | disclosed |
| EP-3966213-A1 | CDK INHIBITORS | Qilu Regor Therapeutics Inc. (CN) | 2022-03-16 | — | — | EP | disclosed |
| WO-2021226140-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2021-11-11 | — | — | WO | disclosed |
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250281487-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | EPHB3 3899/4885MAOB 3929/4885MAPK14 238/4885 |
| US-20240033264-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | EPHB3 4059/4885MAOB 3828/4885MAPK14 196/4885 |
| US-20240066031-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | EPHB3 4059/4885MAOB 3828/4885MAPK14 196/4885 |
| US-20250064806-A1 | CDK INHIBITORS | CDK9, CDK6, CDK3 | EPHB3 3977/4885MAOB 4001/4885MAPK14 190/4885 |
| US-12285429-B2 | CDK inhibitors | CDK9, CDK3, CDKL1 | EPHB3 4033/4885MAOB 4162/4885MAPK14 200/4885 |
| US-20250325544-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | EPHB3 3899/4885MAOB 3929/4885MAPK14 238/4885 |
| US-20250275972-A1 | CDK INHIBITORS | CDK9, CDK6, CDK3 | EPHB3 3977/4885MAOB 4001/4885MAPK14 190/4885 |
| US-20220296595-A1 | CDK INHIBITORS | CDKL1, CDK9, CDK6 | EPHB3 4371/4885MAOB 3911/4885MAPK14 170/4885 |
| US-20230174512-A1 | CDK INHIBITORS | CDK9, CDKL1, CDK3 | EPHB3 4059/4885MAOB 3828/4885MAPK14 196/4885 |
| US-20250275971-A1 | CDK INHIBITORS | CDK6, CDK9, CDKL1 | EPHB3 3899/4885MAOB 3929/4885MAPK14 238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.